OBJECTIVE： To explore the regularity of relative correction factor （RCF） in multi-components by single marker （QAMS）. METHODS： With the source of CNKI， literature retrieval was used to collect the relevant documents of multi-components by single marker （QAMS） and extract the calculated values by quantitative analysis of multi-components by single marker QAMS and measured values by external standard method （ESM）， SPSS 19.0 software was used to calculate the percentage value （RSD， ％） of relative standard deviation between calculated values and measured values， and the correlation between RSD and RCF was analyzed by drawing a scatter plot. RESULTS： Most of RCF values distributed in the range of ＞0.62-1.53， accounting for 76.7％ to all data. Calculated values and measured values showed high similarity in this range and the RSD＜3.0％ data accounted for 88.8％ to all data， which had good credibility. Meanwhile， the similarity of calculated values and measured values was influenced by the differences of structure and physicochemical property of parent nucleus between other components under measured and internal references. The high degree of similarity between calculated values and measured values were decisive by very similar structures of parent nucleus； the low degree was decisive by discrepant structures； and the low degree was also decisive by very similar structures and discrepant physicochemical property of parent nucleus. CONCLUSIONS： RCF will affect the credibility of content determination results for components under measured in QAMS， it is necessary to establish database of RCF， RSD and related parameters.