OBJECTIVE： To observe clinical efficacy and safety of Compound huanglian jiangtang powder for patients with impaired fasting blood glucose（FBG）. METHODS： 122 patients with impaired FBG were selected and randomly divided into control group and trial group with 61 cases in each group. Two groups was given healthy education and diet guidance； trial group was given Compound huanglian jiangtang powder 2.5 g orally， qd. Both groups were treated for 4 months. Clinical efficacy of 2 groups was observed and FBG， TC， TG， LDL-C， HbA1c， SOD， MDA and GSH-PX levels and BMI were observed before and after treatment. The occurrence of ADR was recorded. RESULTS： Total effective rate of trial group was 77.0％， which was significantly higher than that of control group （24.6％）， with statistical significance （P＜0.05）. Before treatment， there was no statistical significance in FBG， TC， TG， LDL-C， HbA1c， SOD， MDA and GSH-PX levels and BMI between 2 groups （P＞0.05）； after treatment， above indexes of 2 groups were improved significantly， the trial group was significantly better than the control group， with statistical significance （P＜0.05）. No obvious ADR was found in 2 groups. CONCLUSIONS： Compound huanglian jiangtang powder is effective improvement of laboratory indexes and safe for impaired FBG.