OBJECTIVE：To observe the short-term efficacy and safety of nimesulide combined with ibuprofen in the treatment of pain. METHODS： 84 patients with pain were randomly divided into observation group and control group. Control group was orally given 0.3 g Ibuprofen sustained-release capsule， twice a day. Observation group was additionally given 100 mg Nimesulide capsule， twice a day. The treatment course for both groups was 7 d. Clinical efficacy， visual analogue （VAS） score， quality of life （QOL） score， coagulation indexes （prothrombin time， thrombin time， fibrinogen， activated partial thromboplastin time） before and after treatment， and incidence of adverse reactions in 2 groups were observed. RESULTS： The total effective rate in observation group was significantly higher than control group， the differences were statistically significant（P＜0.05）. Before treatment， there were no significant differences in the VAS score and QOL score between 2 groups（P＞0.05）. After treatment， VAS scores in 2 groups were significantly lower than before， and observation group was lower than control group， QOL scores were significantly higher than before， and observation group was higher than control group， the differences were statistically significant（P＜0.05）. And there were no significant differences in the coagulation indexes and incidence of adverse reactions between 2 groups（P＞0.05）. CONCLUSIONS： The short-term efficacy of ibuprofen combined with nimesulide is superior to ibuprofen alone in the treatment of pain， with similar short-term safety.