OBJECTIVE： To investigate the application and feasibility of the PDCA cycle management method in pharmacy management of three-level general hospital re-accreditation in our hospital and promote continuous improvement of hospital pharmacy management. METHODS： Referring to 2011 edition of Detailed Rules for Three-level General Hospital Accreditation， the work of hospital pharmacy management was checked and continually improved based on the PDCA cycle management method. RESULTS： After the application of PDCA， prescription error rate in outpatient pharmacy dropped from 0.031 4％ to 0.019 2％； the number of dispense error in center pharmacy decreased by 60.2％ and the accuracy rate of drug stock increased from 87.14％ to 97.32％； the number of dispensing errors in pharmacy intravenous admixture service reduced from 5.6 bags/week to 1.8 bags/week， and the error rate reduced by 67.86％； the proportions of irrational prescriptions of glucocorticoid drugs dropped from 19.26％ to 4.23％. CONCLUSIONS： The application of PDCA cycle management method in pharmacy management of three-level general hospital reaccreditation and the establishment of relevant system can obviously improve the work of pharmacy management continuously.