OBJECTIVE： To provide reference for rational use of antibiotics in patients with AECOPD. METHODS： The pathogen distribution and antibiotics use of AECOPD patients was analyzed in respiratory department of our hospital during 2014-2015. The infection site， pathogen distribution and antibiotics use （including medication purpose， drug name， usage， dosage， medication duration， route of administration， drug combination）， infection and compliance were investigated and analyzed statistically. RESULTS： Among 967 AECOPD patients， there were 619 cases of positive sputum culture （64.01％）. A total of 774 strains were isolated， including 542 strains of Gram-negative bacterial （70.03％） and 232 strains of Gram-positive bacterial （29.97％）； most of them were Pseudomonas aeruginosa （207 strains， 26.72％）. 765 patients were treated with antibiotics， and utilization ratio of antibiotics was 79.11％. 276 cases were treated with one kinds of antibiotics （36.08％）， 435 treated with 2 kinds of antibiotics （56.86％） and 54 treated with 3 kinds of antibiotics and above （7.06％）. Top 3 drugs in the list of frequency were Levofloxacin injection （455 cases/times， 47.05％）， Moxifloxacin injection （241 cases/times， 24.92％） and Cefmetazole for injection （192 cases/times， 19.86％）. Top 3 drug combination regimen were Cefmetazole for injection+Levofloxacin injection （107 cases/times， 21.88％）， Cefoxitin for injection+Levofloxacin injection （96 cases/times， 19.63％） and Moxalactam for injection+Levofloxacin injection （65 cases/times， 13.29％）. CONCLUSIONS： Anti-infective therapy regimen of AECOPD patients should be formulated according to relevant guideline， and pathogenic factors of infection are analyzed. Great importance should be attached to reasonable， scientific， safe and standard use of antibiotics， etiological examination； pathogenic bacteria culture and drug sensitivity test should be conducted as soon as possible. So as to obtain better therapeutic efficacy and reduce the generation of drug-resistant strain.