OBJECTIVE： To provide reference for the prevention and treatment of secondary hospital infection in patients with methamphetamine dependence during the detoxification treatment period. METHODS： The clinical data of 318 patients with methamphetamine dependence in our hospital during detoxification treatment period were analyzed retrospectively from Nov. 2011 to Oct. 2015 in terms of infection rate， the site of infection， infection risk facter and distribution characteristics of pathogenic bacteria and other related factors. RESULTS： Of 318 methamphetamine dependent patients during detoxification treatment period，122 suffered from secondary hospital infection with infection rate of 38.4％. Infection sites mainly involved respiratory system， digestive system； main pathogens were Kelebsiella pneumoniae， Streptococcus pneumeniae and Staphylococcas aureus； high hospital infection rate occurred in patients with combined underlying disease， low albumin level， invasive operation， antibiotics use， low white-cell count， accounting for 53.5％， 58.9％， 47.8％， 47.4％ and 45.9％， respectively. They were risk factors of hospital infection， and there was statistical significance （P＜0.05）. CONCLUSIONS： High secondary hospital infection rate is found in methamphetamine dependent patients during detoxification treatment period， medical staff should actively handle the basic diseases， strictly minimize all kinds of invasive procedures and take multiple measures intervention to reduce hospital infection.