OBJECTIVE： To explore the modes and breakthrough point of clinical pharmacists participating in pharmaceutical care in nephrology department. METHODS： Combined with the practice of nephrology department， the content and method of clinical pharmacists participating in clinical drug therapy were introduced through case analysis. RESULTS： Clinical pharmacists could participated in drug therapy in nephrology department through breakthrough point of paying attention to rational use of ACEI and angiotensin Ⅱ receptor blocker， standardizing drug use before and after renal biopsy paracentesis， drug-induced disease analysis and monitoring，enhancing communication between physicians and nurses， discharged medication education， etc. CONCLUTIONS： Clinical pharmacists provide various types of pharmaceutical care to further promote safe， effective and reasonable use of drugs.