OBJECTIVE：To study the stability of Fuke zhidai capsule at accelerated testing and room temperature. METHODS： HPLC was conducted to determine the content of berberine hydrochloride in the preparation： the column was Diamonsil C18 with mobile phase of B methanol -0.7％ triethylamine（pH adjusted to 3 by phosphate）（50 ∶ 50，V/V） at a flow rate of 1 ml/min； detection wavelength was 265 nm， with a column temperature at 45 ℃， and the injection volume was 5 μl； its moisture， disintegration time， accelerated stability and long-term stability were studied according to the 2015 edition of Chinese Pharmacopoeia. RESULTS： The linear range of berberine hydrochloride was 0.0217-0.1736 mg/ml（r＝0.999 9）； RSDs of precision， stability and reproducibility tests were lower than 2％； recovery was 97.24％-101.73％（RSD＝1.72％，n＝6）. CONCLUSIONS：The moisture， disintegration time， accelerated stability and long-term stability were all in line with the quality standards.