OBJECTIVE： To provide reference for rational use of autibacterial drugs for special use. METHODS： A retrospective analysis was performed of online approval of antibacterial drugs for special use in our hospital. The dates during 2012-2014 period was analyzed on indicators， including the utilization ratio of antibacterial drugs， consumption amount， AUD， submission rate of microbial specimen， resistance rate of major pathogenic bacteria. RESULTS： During 2012－2014， the utilization ratio of antibacterial agents of our hospital for inpatients decreased from 56.17％ to 53.62％， and AUD decreased from 66.50 DDDs/（100 person·d）to 55.53 DDDs/（100 person·d）. The proportion of antibacterial drugs for special use decreased from 12.27％ to 6.72％， and AUD decreased from 8.16 DDDs/（100 person·d）to 3.73 DDDs/（100 person·d）； submission rate of microbial specimen increased from 79.65％ to 91.41％. The main pathogenic bacteria were Escherichia coli， Klebsiella pneumonia， Pseudomonas aeruginosa， Acinetobacter baumannii and Staphylococcus aureus， and their constituent ratio had no significant change； enzyme-producing rate of E. coli increased by 8％， while resistance rate of other bacterials kept stable or decreased. CONCLUSIONS： The approval procedure of antibacterial drugs for special use is standard， convenient and effective， and it significantly improves the indicators of antibacterial use； however， it dosen’t influence the constituent of main pathogens and control resistance rate.