OBJECTIVE： To observe clinical efficacy and safety of Sodium hyaluronate used in the reconstruction of anterior cruciate ligament under arthroscope for the treatment of tibial plateau fracture complicating with cruciate ligament injury. METHODS： 50 patients with tibial plateau fracture complicating with cruciate ligament injury were collected and randomly divided into control group and observation group， with 25 cases in each group. Control group underwent anterior cruciate ligament under arthroscope； observation group was additionally given Sodium hyaluronate 2.5 ml， once a week， for consecutive 5 weeks， on the basis of control group. Clinical efficacy and range of knee joint motion were observed in 2 groups before and after treatment. VAS， bone metabolic markers and ADR were compared between 2 groups after treatment. RESULTS： Total effective rate of observation group was 96.00％ in observation group， which was significantly higher than that of control group （80.00％）， with statistical significance （P＜0.05）. After treatment， range of knee joint motion improved significantly in 2 groups， and the observation group was higher than the control group， with statistical significance （P＜0.05）. After treatment， VAS and bone metabolic markers of observation group were significantly better than those of control group， with statistical significance （P＜0.05）. No obvious ADR was found in 2 groups. CONCLUSIONS： Sodium hyaluronate used in the reconstruction of anterior cruciate ligament under arthroscope  shows good therapeutic efficacy and safety for the treatment of tibial plateau fracture complicating with cruciate ligament injury.