OBJECTIVE： To provide reference for further development of Internet drug transaction services in China. METHODS： The data of online drugstores with top 20 approvals data and sales amount were collected bu the Internet， the normative management was evaluated. Meanwhile， questionnaire was conducted to survey and analyze the cognition， buying drugs and corresponding requirements of some Shanghai citizens for Internet drug retail. RESULTS： By Jun. 12， 2015， totally 307 retail chain drugstores （online drugstores） had got the License of Internet Drugs Transaction， only 62 online drugstores （20.2％） were in full compliance with the normative management； the top 19 online drugstores supplied averagely 1 072±815 OTC medicines， including 259±165 chemical drugs and 813±650 Chinese traditional medicines， and the top 3 were jianke.com （3 658 species）， J1.com （2 071 species） and 360 kad.com （1 523 species）. Totally 216 questionnaires were sent out， and 183 were effectively received with effective recovery of 84.7％. The 183 surveyed citizens showed high cognition in distinguishing the authenticity of online drugstores （75.4％） and the authenticity of drugs （67.1％）， but low cognition in online drugstore opening qualifications and Internet selling drugs； only 22.4％ had the experience of buying drugs online， the degree of satisfaction towards online shopping， from the highest to the lowest， were drug price （62.5％）， professional consultation of pharmacists （50.0％）， variety of drugs （45.0％）， quality of drugs （37.5％）， delivery time（35.0％）， etc.； the most probably purchased medicine category were vitamins and minerals （63.9％） and medicines for common diseases （40.4％）. CONCLUSIONS： Currently the demands and confidence of online drugs shopping of Shanghai citizens are still scarce. Though the access of retailing prescription drugs would spur the Internet drug business， the condition is still immature. It is suggested to sell prescription drugs in a limited way and improve their access threshold， promote Medicare settlement to multi-faceted promote the orderly development of Internet drug transaction services.