OBJECTIVE： To observe the efficacy and safety of amlodipine besylate combined with Xinkeshu in the treatment of hypertension. METHODS： 100 patients with hypertension were randomly divided into control group （50 cases） and observation group（50 cases）. Control group was orally given one Amlodipine besylate tablet， once a day； observation group was additionally given 4 Xinkeshu tablets， 3 times a day. The treatment course was 8 weeks. Clinical efficacy， systolic blood pressure （SBP） and diastolic blood pressure （DBP） before and after treatment in 2 groups were observed， the incidence of adverse reactions was recorded. RESULTS： The total effective rate in observation group was significantly higher than control group， the incidence of adverse reactions was significantly lower than control group， the differences were statistically significant （P＜0.05）. Before treatment， there were no significant differences in the SBP and DBP between 2 groups （P＞0.05）. After treatment， the SBP and DBP in 2 groups were significantly lower than before， the differences were statistically significant （P＜0.05）； but there was no significant difference between 2 groups （P＞0.05）. CONCLUSIONS： The efficacy of amlodipine besylate combined with Xinkeshu is superior to amlodipine besylate alone in the treatment of hypertension， with better safety.