OBJECTIVE： To systematically review the efficacy and safety of Elemene injection combined with chemotherapy in the treatment of gastric carcinoma， and provide evidence-based reference for clinical treatment. METHODS： Retrieved from CBM， CJFD， VIP Database， Wanfang Database， Medline， EMBase， Cochrane Library and American Medical Association Database， randomized clinical trials （RCT） about Elemene injection combined with chemotherapy in the treatment of gastric carcinoma were collected， Meta-analysis was performed by using Rev Man 5.3 software after data extracting and quality evaluating by Cochrane 5.1.0. RESULTS： Totally 7 RCTs were enrolled， involving 434 patients. Results of Meta-analysis showed recent efficacy [RR＝1.38，95％ CI（1.14， 1.67），P＝0.001] and improvement rate of life quality [RR＝1.36，95％ CI（1.15，1.60），P＜0.001] of Elemene injection combined with chemotherapy in the treatment of gastric carcinoma were significantly higher than only chemotherapy. The incidence of Ⅲ-Ⅳ leukemia inhibition [RR＝0.58，95％CI （0.37，0.91），P＝0.02]， incidence of Ⅰ-Ⅳ hemoglobin inhibition [RR＝0.76，95％CI（0.60，0.95），P＝0.02]， incidence of Ⅰ-Ⅳ platelet inhibition [RR＝0.69，95％CI（0.52，0.91），P＜0.001] and Ⅲ-Ⅳ[RR＝0.53，95％CI（0.30，0.93），P＝0.03] and incidence of Ⅰ-Ⅳ neurotoxicity[RR＝0.69，95％CI（0.52，0.93），P＝0.01] in test group were significantly lower than control group， the differences were statistically significant. CONCLUSIONS： Both efficacy and safety of Elemene injection combined with chemotherapy in the treatment of gastric carcinoma are good.