OBJECTIVE：To analysis the correlation of aspirin resistance （AR） in patients with acute recurrent cerebral infarction. METHODS： 208 patients with acute cerebral infarction were divided into primary group （108 cases） and recurrent group （100 cases）. And they were further divided into AR group+aspirin semi resistance （ASR） group and aspirin sensitivity （AS） group based on platelet aggregation rate. The incidences of AR+ASR in primary group and recurrent group were compared； clinical relevant indicators [age， gender， hypertension， high cholesterol， diabetes， coronary heart disease， smoking history， history of excessive alcohol consumption， body mass index （BMI）， high-sensitivity C-reactive protein （hs-CRP）， platelet count （PLT）， fasting plasma glucose （FPG）， triglyceride （TG）， total cholesterol （TC）， high density lipoprotein （HDL） and low density lipoprotein （LDL）] were also compared， and Logistic regression analysis was conducted for the indicators with significant differences. RESULTS： The incidences of AR+ASR in recurrent group were significantly higher than primary group， the differences were statistically significant （P＜0.05）. High cholesterol， diabetes， history of excessive alcohol consumption， hs-CRP and LDL in the AR+ASR subgroups of recurrent group were significantly higher than AS group， the differences were statistically significant（P＜0.05）. Logistic regression analysis showed， high cholesterol[OR＝4.710，95％ Cl（1.985，14.359），P＝0.005]， diabetes [OR＝4.916，95％ Cl（0.962，18.478）， P＝0.038] and hsCRP [OR＝1.002， 95％ Cl（0.653，2.253），P＝0.003] were the risk factors for AR occurrence in recurrent acute cerebral infarction. CONCLUSIONS： The incidence of AR in patients with acute recurrent cerebral infarction is significantly higher than primary patients， and diabetes， high cholesterol and hsCRP may be the risk factors for AR occurrence in recurrent acute cerebral infarction.