OBJECTIVE： To explore the establishment of DUE criteria for the evaluation of glucocorticoids （GCs） use in oncology department of our hospital， and to evaluate the rationality of glucocorticoid use. METHODS： DUE criteria for GCs in our hospital was established preliminary， and used to evaluate medication indication， medication course， medication results， etc. Medical records of 300 patients receiving GCs were collected from oncology department of our hospital during Apr. to Dec. in 2013 （before intervention） and Jun. 2014 to Mar. 2015 （after intervention） via hospital information system. The application of GCs was evaluated. RESULTS： Pexamethasone sodium phosphate injection was used most frequently in our hospital （82.34％）， followed by Dexamethasone acetate tablet （15.33％） and prednisone asetate tablets（2.33％）. The mest common purpose of GCs use in oncology department of our hospital is radiotherapy and chemotherapy induced vomiting prevention and treatment （55.55％ of total case）， followed by anti-inflammatory therapy （14.19％） and chemotheraphy drug pretreatment （12.76％）. After intervention， rational use of GCs for tumor had been improved greatly， and the rate of unqualified drug dosage and medication course decreased from 6.87％ to 3.95％， and that of decreased from 3.58％ to 2.74％. CONCLUSIONS： The establishment of DUE criteria and continuous criteria improvement during clinical rational drug use guidance can promote rational use of GCs in oncology department.