OBJECTIVE： To establish a more improved problem-based learning（PBL） teaching mode and provide reference for the improvement of teaching level in clinical pharmacy teaching. METHODS： PBL teaching mode was established by expert consulting. A case of consultation on a severe heart failure patient with diuretic resistance was used for the standardized training of clinical pharmacist students in class of 2015 in the First Affiliated of chongqing Medical University and the evaluation of PBL teaching method effect. RESULTS： PBL teaching mode could significantly improve the case analysis ability of students. CONCLUSIONS： The established PBL teaching mode is comprehensive， systematic and objective， and can significantly improve the quality of students and teaching level of clinical pharmacists.