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目的:深入了解目前化疗药物引起血糖变化的研究概况,反映相关国家、研究机构和医药科研人员在该领域的科研能力和影响力。方法:以PubMed、中国知网为检索工具,分别以“Drug therapy”“Blood glucose”和“化疗”“血糖”为主题词,检索截至2015年11月7日的所有文献。采用文献计量学方法,对英文文献按国家、城市、刊载期刊、主题词、研究者、他引次数等项目进行排名并分析,对来自我国的英文文献的刊载期刊、城市等项目进行排名并分析;对中文文献研究机构、他引次数等项目进行排名并分析。结果:PubMed检索得到11 445篇文献,英文文献10 095篇(占88.2%),发文量最多的国家为美国(2 356篇);中文文献693篇,研究机构集中在北京、上海、广州等城市。他引次数较高的英文文献主要研究的是血糖的控制,中文文献主要研究的是血糖受到的影响。结论:化疗药物引起血糖变化的临床研究文献逐年递增,仍是临床研究热点。我国的研究尚停留在观察阶段,建议转变为治疗性研究。
OBJECTIVE: To investigate the situation of blood glucose variation induced by chemotherapy drug, and to reflect the scientific research potential and influence of relative countries, institutions and medical research specialist staff. METHODS: All literatures which were published before Nov. 7, 2015, were retrieved from PubMed and CNKI, using “drug therapy”“blood glucose” and “chemotherapy” as keywords. English literatures were ranked in terms of country, city, journals, keyword, researcher, citation frequency, etc., and then analyzed by bibliometrics; English literatures from China were ranked in terms of journals, cities, etc., and then analyzed by bibliometrics; Chinese literatures were ranked in terms of institutions, citation times, etc. and then analyzed by bibliometrics. RESULTS: 11 445 literatures were retrieved from PubMed, involving 10 095 English papers (88.2%); the most literatures were published in America (2 356 pieces); there were 693 pieces of Chinese literatures, mainly from Beijing, Shanghai, Guangzhou and other cities. Most cited English papers focused on how to control blood glucose, while the most cited Chinese ones focused on the influenced blood glucose level. CONCLUSIONS: Literatures about chemotherapy drug inducing blood glucose variation are increasing year by year, and it is the hot point in clinical research. It is suggested to turn the research emphasis from merely observation into treatment.
化疗药物高血糖文献计量分析
Chemotherapy drugHyperglycaemiaBiliometric analysis
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