OBJECTIVE： To discuss the way to develop ADR monitoring in primary retail pharmacy enterprises， and to improve ADR monitoring in China. METHODS： The situation of ADR monitoring in 6 retail pharmacy enterprises （212 retail stores and 295 single retail stores） from 18 towns and streets of Cixi city were analyzed as well as its influential factors. RESULTS & CONCLUSIONS： The employees did not realize the importance of obtaining knowledge about ADR and developing ADR monitoring； professional level of medicine practitioners was limited， pharmaceutical technical services were not provided effectively， and it was difficult to collect， register or report ADR information； the management system was defective within the enterprise， and specific measures to ADR monitoring were lacking. It is suggested to strengthen the publicity and education of ADR monitoring， enhance the ADR monitoring knowledge training to medicine practitioners， lead licensed pharmacists to provide pharmaceutical technical services actively， give full play to the "leader" role of the pharmaceutical retail chain enterprises to guide monomer drugstores to carry out the ADR monitoring， and improve the legal system and intensify supervision， so as to promote the development of ADR monitoring in primary retail pharmacy enterprises and provide protection for safe drug use.