OBJECTIVE：To improve the quality standard of Shexiang qutong liniment. METHODS： TLC was used for qualitative identification of Resina draconis and Rehmannia. The determination of total solids and ether-soluble extracts in the preparation was detected. GC was used for the content determination of muscone： the column was Thermo-TG-WAXMS capillary column by programmed temperature， the detector was FID detector， the detector temperature was 250 ℃， inlet temperature was 200 ℃， carrier gas was high purity nitrogen at a flow rate of 1.0 ml/min， split ratio was 5 ∶ 1， and the injection volume was 1 μl. RESULTS：The TLC pots of R.draconis and Rehmannia were clear with good separation. The total solids in preparations were not less than 0.6％， and extracts were not less than 3.0％. The linear range of muscone concentration was 15.21-243.36 μg/ml（r＝0.999 8）； RSDs of precision， stability and reproducibility tests were lower than 2％； recovery was 97.70％-99.63％（RSD＝0.78％，n＝6）. CONCLUSIONS： The established method can be used for the quality control of Shexiang qutong liniment.