OBJECTIVE: To introduce the application of intelligent sorting system for prepared infusion in PIVAS of our hospital. METHODS: Intelligent sorting system established by our hospital with barcode scanning technology and relevant hardware devices such as automatic drug sorting devices was introduced from system operation environment, system software design and system function. The effects of the system was evaluated through comparing with manual sorting mode. RESULTS: The intelligent sorting system used had such functions as sorting batch selection, intelligent sorting and discharging, information tracing management. Compared to manual sorting, the number of staff under intelligent sorting mode decreased from 7 to 2, sorting errors within 3 months were reduced by 99.0% (591 times vs. 6 times), and the daily sorting errors were reduced by 98.9% (6.57 times vs. 0.07 times). CONCLUSIONS: The system runs stably and sorts accurately, the errors is reduced, the working efficiency is improved and intensity of sorting is reduced, compared to manual sorting.