OBJECTIVE： To investigate the measures and roles of pharmaceutical care in improving the safety of chemotherapy by clinical pharmacists. METHODS： Chemotherapy drug-induced ADR medical records were collected from oncology department of our hospital during Jan.-Dec. 2013 （before intervention） and Apr. 2014-Mar. 2015 （after intervention）， and then analyzed and compared in respects of chemotherapy plan， patient’ age and gender， route of administration， involved organs and systems， severe ADR， etc. RESULTS： After the formulation and implementation of pharmaceutical care for improving safe use of chemotherapy drugs， the incidence of chemotherapy drugs-induced ADR decreased from 88.48％ to 72.14％； the incidence of ADR of involved digestive system， skin and its appendants decreased from 67.28％ and 7.37％ to 42.29％ and 1.99％， respectively； the incidence of severe nausea and vomiting decreased from 27.65％ to 18.91％； the constituent ratio of single agent chemotherapy and oral administration route increased from 31.80％（69/217） and 14.29％（31/217） to 44.28％（89/201） and 22.39％（45/201）， respectively （P＜0.05）.  CONCLUSIONS： Pharmaceutical care intervention measures formulated by clinical pharmacists can significantly lower the incidence of ADR， promote safe use of chemotherapy drugs and guarantee the safety of drug use.