OBJECTIVE： To observe therapeutic efficacy of Yiqi qingfei decoction combined with chemotherapy in the treatment of elder advanced non-small cell lung cancer （NSCLC）. METHODS： 76 elder patients with NSCLC were randomly divided into control group and observation group， with 38 cases in each group. Both groups were given hydration， antiemetics and tropisetron+dexamethasone therapy. Control group was given Vinorelbine bitartrate injection 25 mg/m2+normal saline diluted to 125 ml， ivgtt within 10 min on the first and eighth day； given Cisplatin injection 30 mg/m2+normal saline 500 ml， ivgtt within 3 h. Observation group was addtionally given Yiqi qingfei decoction 200 ml one dose a day， at twice on the basis of control group. Both group were given 2 months of treatment. The clinical efficacy， and blood coagulation， T cell immune function， survival time and survive quality before and after treatment were observed in 2 groups. RESULTS： The total effective rate of observation group was 63.1％， which was significantly higher than that of control group （34.2％）， with statistical significance （P＜0.05）； there was no statistical significance in blood coagulation and T cell immune function of 2 groups before and after treatment（P＞0.05）； after treatment， fibrinogen （FIB）， D-dimer （D-D） and CD8+ levels of observation group were significantly reduced， while CD3+， CD4+ and CD4+/CD8+ were significantly increased， with statistical significance compared to before treatment and control group （P＜0.05）； median survival time of observation group was 10.2 month， which was significantly longer than that of control group （7.6 month）， with statistical significance （P＜0.05）； before treatment， there was no statistical significance in survival quality score between 2 groups （P＞0.05）； after treatment， the survive quality scores of observation group were significantly lower than that of control group， with statistical significance （P＜0.05）. CONCLUSIONS： For elder patients with NSCLC， Yiqi qingfei decoction combined with chemotherapy is help to improve the blood coagulation and immune function， extend the survival time， and improve the survive quality.