OBJECTIVE： To provide reference for further standardizing the instructions of domestic third-generation aromatase inhibitors （AIs）. METHODS： According to Instruction and Label Management Regulations， Chemical Drugs and Biological Products Instruction Detail Rules and other references， the domestic and foreign instructions of third-generation AIs were analyzed comparatively in terms of ADR， precautions， drug interaction， pharmacology and toxicology， pharmacokinetics and the modification times， etc. RESULTS & CONCLUSIONS： Compared with 3 foreign AIs instructions， the instructions of 10 domestic AIs were relatively complete in structure and items， but the key projects were not marked in detail， including ADR，precautions，drug interaction，pharmacology and toxicology and pharmacokinetics. At the same time， the instruction of domestic AIs were not timely revised. It is suggested to strengthen standardizing domestic pharmaceutical producing enterprise and perfecting item labelling management of drug instructions so as to guarantee safe and effective use of drugs in the clinic.