OBJECTIVE： To observe analgesic effect and safety of ketorolac tromethamine combined with butorphanol tartrate in the treatment of acute pain after fracture surgery. METHODS： 76 acute pain patients after fracture surgery were selected and randomly divided into control group and observation group， with 38 cases in each group. Control group was given Ketorolac tromethamine injection 30 mg，ivgtt， and then 2 ml/h， 0.5 mg/kg， ivgtt； observation group was additionally given butorphanol tartrate 10 mg，ivgtt， on the basis of control group. Pain degree was evaluated with VAS before and 10 min， 1， 2， 4 and 6 h after treatment， and the occurrence of ADR was observed in 2 groups. RESULTS： 10 min， 1， 2， 4 and 6 h after treatment， VAS score of 2 groups were significantly  lower than before， with statistical significance （P＜0.05）； 6 h after treatment， VAS score of observation group was significantly higher than that of control group， with statistical significance （P＜0.05）； there was no statistical significance in VAS score between 2 groups 10 min， 1， 2 and 4 h after treatment （P＞0.05）. The incidence of ADR in observation group （5.26％） was significantly lower than in control group （21.05％）， with statistical significance （P＜0.05）. CONCLUSIONS： Compared with ketorolac tromethamine alone， ketorolac tromethamine combined with butorphanol tartrate shows shorter analgesia duration， similar therapeutic efficacy， and lower incidence of ADR.