OBJECTIVE：To establish a method for contents determination of salvianic acid A sodium， protocatechualdehyde， calycosin-7-glycoside， liquiritin， salvianolic acid B and salvianolic acid A. METHODS： HPLC was performed on the column of Sepax Sapphire-C18 with mobile phase of acetonitrile-0.2％ formic acid （gradient elution） at a flow rate of 0.8 ml/min， the detection wavelength was 283 nm，the column temperature was 25 ℃， and the injection volume was 10 μl. RESULTS： The linear range was  25.00-400.00 μg/ml for salvianic acid A sodium（r＝0.999 9），2.50-40.00 μg/ml for protocatechualdehyde（r＝0.999 9），   5.00-80.00 μg/ml for calycosin-7-glycoside（r＝0.999 9），6.25-100.00 μg/ml for liquiritin （r＝0.999 9）， 18.75-300.00 μg/ml for salvianolic acid B（r＝0.999 8） and 5.00-80.00 μg/ml for salvianolic acid A（r＝0.999 8）； RSDs of precision， stability and reproducibility tests were lower than 2.0％； recoveries were 101.52％-102.24％（RSD＝0.23％，n＝6），96.25％-99.25％（RSD＝1.06％，n＝6），99.80％-101.80％（RSD＝0.75％，n＝6），96.60％-100.00％（RSD＝1.29％，n＝6），96.51％-99.77％（RSD＝1.20％，n＝6） and 97.09％-102.00％（RSD＝1.91％，n＝6），respectively. CONCLUSIONS：The method is simple， accurate and reproducible， and can be used for simultaneous determination of salvianic acid A sodium， protocatechualdehyde， calycosin-7-glycoside， liquiritin， salvianolic acid B and salvianolic acid A in Yixinyin oral solution.