OBJECTIVE：To evaluate the methodological bias of systematic review and the reliability of counclusions of traditional Chinese medicine （TCM） combined with transarterial chemoembolization in the treatment of primary liver cancer， and provide evidence-based reference. METHODS： Retrieved from Cochrane Library， PubMed， Guideline， CBM，CJFD and Wanfang Database， high quality systematic review about TCM combined with transarterial chemoembolization in the treatment of primary liver cancer was collected for reevaluation. RESULTS： Totally 12 systematic review were involved. Results showed TCM combined with transarterial chemoembolization can improve tumor’s objective response， prolong the survival time of patients， improve life quality， reduce postoperative adverse reactions with no serious adverse reactions reported related to TCM in the treatment of primary liver cancer. CONCLUSIONS： The clinical efficacy of TCM combined with transarterial chemoembolization is superior to transarterial chemoembolization alone in the treatment of primary liver cancer， with better safety.