OBJECTIVE： To observe the clinical efficacy and safety of Compound methoxyphenamine combined with montelukast sodium in the treatment of post-infectious cough （PIC）. METHODS： 200 PIC patients meeting diagnosis criteria were randomly divided into control group and observation group， with 100 cases in each group. Control group was given Compound methoxyphenamine tablet， 2 tablets/time， tid； observation group was additionally given Montelukast sodium tablet 10 mg， qd， on the basis of control group. Treatment course lasted for 10 days. The day and night coughing score， total clinical effective rate before and after treatment and ADR in 2 groups were compared. RESULTS： Before treatment， there was no statistical significance in day and night coughing score between 2 groups （P＞0.05）. After treatment， the day and night coughing score of observation group were significantly lower than that of control group， with statistical significance （P＜0.05）. Total effective rate of observation group （82.00％） was significantly higher than that of control group （66.00％）， with statistical significance （P＜0.05）. No sereve ADR was found in 2 groups. CONCLUSIONS： The efficacy and safety of compound methoxyphenamine combined with montelukast sodium are better than Compound methoxyphenamine alone in the treatment of PIC.