OBJECTIVE：To explore the effects of atorvastatin combined with allopurinol on blood lipid and blood uric acid in patients with hyperlipidemia and hyperuricemia. METHODS：90 patients with hyperlipidemia and hyperuricemia were randomly divided into group A， group B and group C. Group A was orally given 0.1 g Allopurinol tablet， once a day+30 mg Atorvastatin calcium tablet， once a day. Group B was given Atorvastatin calcium tablet （the same dose with group A）. Group C was given Allopurinol tablet （the same dose with group A）. The treatment course for all groups was 4 weeks. TG， TC， LDL， HDL， UA， BUN， ALT and CK before and after treatment， and incidence of adverse reactions in all groups were observed. RESULTS：After treatment， TG， TC and LDL in all groups were significantly lower than before， group A and B were lower than group C， the differences were statistically significant （P＜0.05）； UA in all groups was significantly lower than before， group A and B were lower than group C， group A was lower than group B， the differences were statistically significant（P＜0.05）； ALT in group A and B， CK in all groups and BUN levels in group A and group C were significantly higher than before， CK in group A and group B higher than group C， group A was higher than group B， the differences were statistically significant（P＜0.05）. And there was no significant difference in the incidence of adverse reactions among all groups（P＞0.05）. CONCLUSIONS：Atorvastatin combined with allopurinol can significantly reduce the blood lipid and blood uric acid levels of patients， with good safety.