OBJECTIVE： To observe the clinical effect and safety of TCM preparation Tianxuanqing injection combined with conventional western medicine treatment for Meniere’s disease. METHODS： 102 patients diagnosed as Meniere’s disease were selected retrospectively and divided into study group （53 cases） and control group （49 cases） according to treatment methods. Both groups received conventional western medicine treatment （dextran-40 500 ml added into ATP， coenzyme A for intravenous dripping， qd， oral administration of diazepam）， and study group was additionally given Tianxuanqing injection 600 mg added into 5％ Glucose injection or normal saline ivgtt， qd for adjunctive therapy. A treatment course lasted for 7 d both groups received 2 courses of treatment. RESULTS： After treatment， DHI of 2 groups decreased compared to before treatment， study group was lower than that of control group， with statistical significance （P＜0.05）； total effective rate of study group （83.02％） was higher than that of control group （61.22％）， with statistical significance （P＜0.05）. The rate of hearing improvement in study group （88.68％） was higher than in control group （73.47％）， with statistical significance （P＜0.05）. No obvious ADR was found in 2 groups. CONCLUSIONS： TCM preparation Tianxuanqing injection assisting conventional western medicine treatment shows significant clinical effect on Meniere’s disease and can obviously improve vertigo and hearing symptom， with good safety.