OBJECTIVE：To systematically review the effectiveness and safety of Yinzhihuang oral liquid in the adjuvant treatment of neonatal jaundice， and provide evidence-based reference for clinical treatment. METHODS：Retrieved from CJFD， VIP Database， Wanfang Database， Medline and EMBase， randomized controlled trials （RCT） about the effectiveness of Yinzhihuang oral liquid （test group） based on the canventional treatment （control group） in the adjuvant treatment of neonatal jaundice were collected， and Meta-analysis was performed by using Rev Man 5.2 software after data extracting and quality evaluating by modified Jadad. RESULTS：Totally 12 RCTs were enrolled， involving 1 585 patients. Results of Meta-analysis showed total effective rate [OR＝0.19，95％CI（0.12， 0.30），P＜0.001]， serum total bilirubin levels [MD＝－40.78，95％CI（－42.68，－38.89），P＜0.001] and time of bilirubin decreased to normal [MD＝－2.56，95％CI（－2.72，－2.40），P＜0.001] in test group were significantly better than control group， the differences were statistically significant between 2 groups； 3 reports of adverse reactions showed scme children had vomiting and mild diarrhea， they were improved after symptomatic treatment， and it did not affect the treatment. CONCLUSIONS： The effectiveness of Yinzhihuang oral liquid is good in the adjuvant treatment of neonatal jaundice， with mild adverse reactions.