OBJECTIVE： To provide reference for rational use of antibiotics in community-acquired pneumonia （CAP） patients. METHODS： Medical records of 342 CAP inpatients in our hospital during Jan.-Dec. in 2014 were analyzed retrospectively by DDDs and SPSS 19.0 statistical software. According to the age， the patients were divided into youth group， the young group， middle age group and elderly group， and clinical information and the use of antibiotics were analyzed statistically. RESULTS： Microbiological examination of 320 of 342 CAP inpatients were performed with detection rate of 93.57％； sputum culture， blood culture and PCT were conducted in 67 case to find out pathogenic bacteria with negative rate of 20.18％. 338 patients had used antibiotics （98.83％）， and other 4 patients refused anti-infective treatment. Selected empirical antibiotics of our hospital were mainly β-lactam （50.07％）， quinolones （35.70％） and macrolides （9.80％）. CAP inpatients were mainly given two-drug therapy， of which cephalosporin combined with quinolone were most common， including 178 cases in total （53.61％）. During treatment， 17 patients suffered from ADR， with incidence of 5.03％. CONCLUSIONS： The detection rate from patients with CAP in our hospital is high in microbiological examination， but culture results should be analyzed dialectically according to clinical signs. Empirical anti-infective therapy mainly include β-lactams， quinolones and macrolides antibiotics alone or in combination with， basically meet the guideline for CAP Diagnosis and Therapy Guideline.