OBJECTIVE：To establish the quality standard for Xugu liaoshang cream. METHODS：TLC was used to identify Cinnamomum cassia and Reynoutria japonica； HPLC was used to determine the content of asperosaponin Ⅵ. The column was Wondasil C18 with mobile phase of acetonitrile-water （30 ∶ 70，V/V） at a flow rate of 1.0 ml/min， the detection wavelength was 212 nm， and the column temperature was 30 ℃. RESULTS： The TLC graph of C.cassia and R.japonica showed clear pots and good separation. The linear range of asperosaponin was 0.204 3-1.225 6 μg （r＝0.999 5）； RSDs of precision， stability and reproducibility tests were lower than 2％； recovery was 95.94％-99.80％（RSD＝1.43％，n＝6）. CONCLUSIONS： The established standard can be used for the quality control of Xugu liaoshang cream.