OBJECTIVE： To investigate the protective and prognosis effects of Shengfu injection on viscera function in patients underwent emergency cardiopulmonary resuscitation. METHODS： 82 patients with cardiac arrest were randomly divided into control group （40 cases） and observation group （42 cases）. Both group received cardiopulmonary resuscitation and routine treatment； observation group was additionally given intravenous injection of Shenfu injection 20 ml immediately after cardiopulmonary resuscitation， every 15 min， 5 times in total， 100 ml via intravenous drip since the next day （0.9％ Sodium chloride injection diluted to 400 ml）， qd， for 7 days. CRP， TNF-α， ALT， urine Cr and CK levels were determined in two groups， respectively. Mean arterial pressure and heart rate were recorded， and coma degree was scored by using GCS， and ADR was observed. RESULTS： 24 and 48 h after cardiopulmonary resuscitation， the serum levels of CRP and TNF-α in observation group were significantly lower than in control group， with statistical significance （P＜0.05）. 6， 12 and 48 h after cardiopulmonary resuscitation， mean arterial pressure of observation group were significantly higher than that of control group，with statistical significance （P＜0.05）. 12， 48 h after cardiopulmonary resuscitation， the GCS score in observation group was significantly higher than control group， with statistical significance （P＜0.05）. There was no statistical significance in heart rate between 2 groups at different time points （P＞0.05）. ALT， urine Cr and CK of observation group were all lower than those of control group 48 and 72 h after cardiopulmonary resuscitation， with statistical significance （P＜0.05）. No ADR was found in 2 groups. CONCLUSIONS： Shenfu injection shows a certain protective effect on viscera function in patients underwent cardiopulmonary resuscitation and improve prognosis.