OBJECTIVE： To discuss the general rule and characteristics of Compound glycyrrhizin-induced ADR. METHODS： Retrieved from Wanfang database and CNKI， Compound glycyrrhizin-induced ADR reports published on domestic medical journals were analyzed statistically during Jan. 2010 to Dec. 2015. RESULTS： 27 literatures were collected， involving 34 ADR cases. The propertion of male was more than that of female （58.82％ vs. 41.18％）； ADR often occurred in patients aged more than 50 years；main route of administration was injection （30 cases， 88.24％）； ADR mainly occurred with 30 min after medication （13 cases， 38.23％）； main ADR were organ/system and systemic damage （21 times， 24.70％）， and allergic shock was the most common clinical manifestation. 34 cases received symptomatic treatment after drug withdrawal and obtain good prognosis. There was no death case. CONCLUSIONS： Compound glycyrrhizin is commonly applied in clinic， which should strictly abide by the indications. Great importance should be attached to medication monitoring， especially in patients aged more than 50 years and pre-medication education to reduce the occurrence of ADR.