OBJECTIVE：To explore the effects of hydrochlorothiazide combined with phentolamine on related indicators of hypertensive emergency. METHODS： 150 patients with hypertensive emergency were randomly divided into phentolamine group， hydrochlorothiazide group and combination group. All patients were given Captopril tablet and other Conventional treatment. Based on it， phentolamine group was given 20 mg Phentolamine mesylate injection， adding into 250 ml 5％ Glucose injection by intravenous infusion， with drip rate of 30-40 mg/min； hydrochlorothiazide group was given 50 mg Hydrochlorothiazide tablet， orally. Combination group was given Hydrochlorothiazide tablet （the same dosage with hydrochlorothiazide group） + Phentolamine mesylate injection （the same dosage with phentolamine group）. Systolic blood pressure （SBP）， diastolic blood pressure （DBP）， arterial pressure （MAP）， heart rate （HR）， cardiac index （CI） and the peripheral resistance （TPRI） in all groups were observed after 10， 30 and 60 min. RESULTS： After treatment， the SBP， DBP， MAP and TPR levels in combination group and phentolamine group were significantly lower than before and gradually decreased by time extension，and combination group was lower than phentolamine group and hydrochlothiazide group，CI level was significantly higher than before and gradually increased by time extension，and combination group was higher than phentolainine group and hydrochlothiazide group； after 60 min， SBP， DBP， MAP and TPRI levels in hydrochlorothiazide group were lower than before and after 10 and 30 min， CI level was higher than before and after 10 and 30 min， the differences were statistically significant（P＜0.05）. And there was no significant difference in the incidence of adverse reactions （P＞0.05）. CONCLUSIONS：Based on the conventional treatment， hydrochlorothiazide combined with phentolamine can significantly improve the blood pressure and cardiac functions， with good safety.