OBJECTIVE： To study the improvement effect of Shenqi jiangtang granules on blood glucose and blood lipid in type 2 diabetic model rats and its dose-effect relationship. METHODS： 90 rats were randomly divided into normal group （water， 12 rats） and experimental group （78 rats）. The experimental group was given high fat diet and streptozotocin intraperitoneally to induce type 2 diabetic model， and 60 model rats were randomly divided into model group （water）， positive control group （Rosiglitazone tablet， 0.04 mg/100 g）， Shenqi jiangtang granule low-dose， medium-dose and high-dose groups （0.025， 0.05 and 0.1 g/100 kg， SL， SM and SH groups）； they were given relevant medicine intragastrically once a day for 30 days. The body weight， fasting blood glucose （FBG）， fasting insulin （Fins）， fasting C-peptide and serum levels of blood urea nitrogen （BUN）， total cholesterol （TC）， glycerin trilaurate （TG）， LDL-C and HDL-C were determined. RESULTS： Compared with normal group， body weight， fasting C-peptide and HDL-C decreased in model group， while BUN， FBG， Fins， TC and TG increased （P＜0.05）. Compared with model group， the levels of BUN， FBG， Fins， TC and TG decreased in treatment groups while fasting C-peptide and HDL-C increased； body weight of rats increased in positive group， SM and SH groups （P＜0.05）. Compared with SL group， the levels of FBG， Fins， TC， TG and LDL-C decreased in positive group， SM and SH groups， while the level of fasting C-peptide increased； the level of BUN decreased in positive control group and SH group， while HDL-C increased （P＜0.05）. Compared with SM group， the levels of TG and LDL-C decreased in positive control group and SH group， while HDL-C level increased； the levels of FBG， Fins and TC decreased in SH group， while the level of fasting C-peptide increased （P＜0.05）. CONCLUSIONS： Shenqi jiangtang granules can improve blood glucose and lipid in type 2 diabetic model rats in a dose-dependent manner.