OBJECTIVE： To analyze the correlation between CYP3A5（6986A＞G） gene polymorphism and ADRs caused by docetaxel in order to provide suggestions for reducing the ADR caused by docetaxel. METHODS： In prospective cohort study， pyrosequencing was adopted to detect CYP3A5 genotype （6986A＞G）. Dominant genetic model was established， and the correlation between genotype and ADR caused by docetaxel was evaluated by SPSS 20.0. RESULTS： 117 patients were included. Among them， the number of wild type （AA）， mutation heterozygous type （AG）， mutation homozygous type （GG） was 3， 30 and 84 respectively.  Dominant genetic model showed that the incidence of peripheral neurotoxicity and finger/toe nail toxicity in group GG was significantly higher than that of （AA+AG） group， with statistical significance（P＜0.05）. CONCLUSIONS： CYP3A5 （6986A＞G）GG genotype significantly increase the incidence of peripheral neurotoxicity and finger/toe nail toxicity caused by docetaxel.