OBJECTIVE： To investigate the effects of anisodamine combined with oxytocin on labor process of lying-in women with prolonged active phase in the first labor process and related indicators of newborns. METHODS： 216 lying-in women with prolonged active phase in the first labor process were randomly divided into control group（108 cases） and observation group（108 cases）. All lying-in women were artificially ruptured， based on it， control group was given 2.5 u Oxytocin for injection， adding into 500 ml 5％ Glucose injection by intravenous infusion， the drip rate was appropriately adjusted based on contractions； observation group was additionally given 10 mg raceanisodamine hydrochloride， adding into 10 ml 5％ Glucose injection by intravenous infusion by 5 min slow intravenous injection. The fetal heart was warded to closely observe the labor process during medication. The cervical maturity， labor process time， delivery mode and postpartum situation of lying-in women， Apgar score， body mass and incidence of adverse reactions of newborn in 2 groups were observed. RESULTS： The lying-in women cases with no less than 9 cervical maturity， natural delivery rate and 5 min newborn Apgar score in observation group were significantly higher than control group，  lying-in women cases with 7-9 scores and less than 7 scores， cesarean section rate， perineal / straight cut rate and 24 h postpartum hemorrhage were significantly lower than control group， the second， the third and total labor process were significantly shorter than control group， the differences were statistically significant （P＜0.05）； there were no significant differences in the time of incubation period and active period， forceps delivery rate， body mass of newborn and incidence of adverse reactions in 2 groups （P＞0.05）. CONCLUSIONS： Anisodamine combined with oxytocin can accelerate the cervical dilation of lying-in women with prolonged active phase， shorten labor process， reduce cesarean section rate and improve prognosis， it did not affect the body mass of newborns，with good safety.