OBJECTIVE：To analyze the rationality of tamoxifen for ovulation induction，and to provide reference for the standardization of off-label use of tamoxifen. METHODS：Taking“tamoxifen”，“ovulation induction”and“polycystic ovarian syndrome” as keywords，relevant literatures about off-label use of tamoxifen for ovulation induction were analyzed and summarized by a search of CNKI，Wanfang database，PubMed database up to July 2015. RESULTS：58 literatures were searched，among which clinical trial or systematic review about the effect of tamoxifen on ovulation induction were selected. 11 valid literatures were collected to confirm clinical efficacy of tamoxifen for ovulation induction. Referring to Diagnosis and Treatment of Polycystic Ovary Syndrome：An Expert Consensus，pharmaceutical affairs council of our hospital had agreed to off-label use of tamoxifen for induction ovulation，and formulated the standard of off-label use of tamoxifen. CONCLUSIONS：Standard management of off-label use of tamoxifen could be better protect the rights both of patient and doctor