OBJECTIVE: To understand the influential factors of clinical pharmacy service satisfaction, and provide reference for improving the pharmacy service. METHODS: Questionnaire survey was adopted to investigate and analyze the influential factors about satisfaction of parts of patients from 23 hospitals in Zhejiang province on pharmacy service from aspects of ease of taking medicines, perceived quality, pharmacy services expectations, perceived value, patients’ feelings and complaints based on structural equation. RESULTS: Totally 500 questionnaires were sent out and 413 were valid with effective rate of 82.6%. The established model included 19 observed variables and 6 latent variables; results showed ease of taking medicines had positive effect on perceived quality, pharmacy services expectations, perceived value and patients’ feelings, and most affected on patients’ feelings (satisfaction); pharmacy services expectations had positive correlation with patients’ feelings; perceived value had negative correlation with patients’ complaints. CONCLUSIONS: In order to improve the satisfaction of patients, the professionalism and service attitude of pharmacy staffs, ease of taking medicines of patients and psychological and social satisfaction degree should be improved.