OBJECTIVE：To establish a method for the determination of content and content uniformity in Lovastatin dispersible tablet，to provide reference for the quality control of its peneric production and storage period. METHODS： HPLC method was adopted on the column of Waters MS C18 with mobile phase of acetonitrile-0.01％ phosphoric acid （55 ∶ 45，V/V）， detection wavelength was 238 nm， column temperature was 30 ℃， flow rate was 1.0 ml/min， and the volume injection was 20 μl. RESULTS： The linear range of lovastatin was 20.32-609.60 μg/ml （r＝0.999 9）； RSDs of precision， stability and reproducibility tests were lower than 1％； recovery was 99.60％-101.68％ （RSD＝0.8％，n＝9）. CONCLUSIONS： The method is reproducible with high accuracy， and suitable for the quality control of Lovastatin dispersible tablet.