OBJECTIVE： To investigate the effect of Xuebijing injection on coagulation function and prognosis in patients with sepsis. METHODS： 50 patients with sepsis were randomly divided into control group and observation group according to the hospitalization sequence， with 25 cases in each group. Control group received conventional treatment， and observation group was additionally given Xuebijing injection （50 ml added into 5％ Glucose solution or 0.9％ Sodium chloride solution 250 ml intravenously， bid） on the basis of conventional treatment. Treatment course lasted for 7 d. The coagulation function， APACHE Ⅱ score after 7 days of treatment and 28 d mortality were compared between 2 groups. RESULTS： After 7 d treatment， the coagulation indexes were improved significantly in 2 groups compared with before treatment， and the APACHEⅡscores were decreased significantly in both groups； the observation group were significantly better than the control group， with statistical significance （P＜0.05）. After followed up for 28 d， the mortality rate of 2 groups were 16％ and 28％， there was no statistical significance （P＞0.05）. CONCLUSIONS： Xuebijing injection can inhibit blood clotting activation， correct the coagulation disorders， and improve the sepsis severity.