OBJECTIVE：To explore the risk factors of antituberculosis drug-induced liver injury， and provide scientific basis for the prevention and treatment of drug-induced liver injury. METHODS： Retrospective analysis was adopted to investigate 410 patients with antituberculosis treatment， single factor and multi-factor Logistic regression analysis were adopted to analyze the risk factor that may induce liver injury in antituberculosis treatment. RESULTS： Single factor regression analysis showed that gender， hepatitis history and drinking history were associated with drug-induced liver injury， multi-factor  regression analysis showed that female（OR＝2.320，P＝0.021），hepatitis history（OR＝4.332，P＝0.006），drinking history（OR＝4.512，P＝0.003） and malnutrition（OR＝3.202，P＝0.015） were risk factors of antituberculosis drug-induced liver injury， and the degree of danger was drinking history＞hepatitis history＞malnutrition＞female. CONCLUSIONS：The antituberculosis drug-induced liver injury is mainly affected by female， hepatitis history， drinking history and malnutrition， the prevention of drug-induced liver injury based on related risk factors is helpful to improve the clinical symptoms and reduce the incidence of adverse reactions.