OBJECTIVE：To promote the rational use of anti-cold drugs in primary hospital. METHODS：The anti-cold drugs commonly used in outpatient pharmacy of Chinese and western of our hospital were investigated to summarize and analyze the western drugs and Chinese patent drugs. RESULTS：There were totally 33 anti-cold drugs，including 12 kinds of western drugs and 21 kinds of Chinese patent drugs. Mostly anti-cold western drugs were compound preparations，mainly including 5 ingredients：anti-inflammatory， vasoconstrictor，antitussive，antihistamine and expectorant；the wind-cold common cold and wind-heat common cold should be differentially treated and the role of the characteristics should be grasped. CONCLUSIONS：Physicians and pharmacists should fully understand and grasp the composition，content，indications，the role of the characteristics，adverse reactions and precautions. Different drugs should be given corresponding medication guide based on the clinical symptoms of the patients.