OBJECTIVE：To systematically review the efficacy and safety of Xiyanping injection versus Ribavirin injection in the treatment of herpangina in children，and provide evidence-based reference for clinical treatment. METHODS：Retrieved from PubMed，Cochrane Library，EMBase，VIP Database，CJFD，Wanfang Database and CBM，randomized controlled trials（RCT） about efficacy and safety of Xiyanping injection versus Ribavirin injection in the treatment of herpangina in children were collected. Meta-analysis was performed by using Rev Man 5.3 software after data extracting and quality evaluating by modified Jadad. RESULTS： Totally 14 RCTs were enrolled，involving 1 939 patients. Results of Meta-analysis showed total effective rate [OR＝4.69， 95％CI（3.36，6.55），P＜0.001]，fever clearance time [MD＝－1.36，95％ CI（－1.60，－1.12），P＜0.001]，herpes regression time [MD＝－1.34，95％CI（－1.61，－1.06），P＜0.001]，hospitalization time [MD＝－1.88，95％ CI（－3.68，－0.07），P＝0.04] and salivation disappearance time [MD＝－1.07，95％ CI（－1.30，－0.84），P＜0.001] of Xiyanping injection were significantly better than Ribavirin injection，there were statistically significant differences. And there was no significant difference in the incidence of adverse reactions [OR＝0.56，95％ CI（0.31，1.03），P＝0.06]. CONCLUSIONS：The efficacy of Xiyanping injection is better than Ribavirin injection in the treatment of herpangina in children，with similar safety.