OBJECTIVE： To provide reference for the development of precision medicine and its economic evaluation of precision medicine and scrutinize methodological issues. METHODS： The concept and characteristics of precision medicine， and the situation of economic evaluation were introduced， and the methodology of economic evaluation was also commented. RESULTS&CONCLUSIONS： The United Kingdom， United States and Australia already have certain research and practice of economic evaluation of precision medicine.Comprehensive considerations should be taken into account like the character and change of clinical efficacy， research design and control group， cost definition， health outcome metrics and threshold of willingness to pay， compared to conventional medical model. The evaluation design of precision medicine and model construction will be further studied in order to achieve scientific and reasonable economic evaluation effect.