OBJECTIVE：To investigate the curative effect and economics of prostaglandins drugs in the treatment of glaucoma， and to provide reference for clinical medication. METHODS：In retrospective study，a total of 790 glaucoma patients were divided into latanoprost group（62 cases），travoprost group（356 cases）and bimatoprost group（372 cases）according to therapy regimen. They were given relevant medicine. Total effective rate of 3 groups were calculated，and the cost-minimization method was used for pharmacoeconomics evaluation. RESULTS：The total effective rate of 3 groups were 87.10％，84.27％，76.08％ respectively， without statistical significance（P＞0.05）. The cost of them were 208.00 yuan，225.00 yuan and 173.00 yuan，and that of bimatoprost group was the lowest. The results of sensitivity analysis was in line with that of cost-minimization analysis. CONCLUSIONS： For glaucoma，bimatoprost is more economical than latanoprost and travoprost.