OBJECTIVE：To systematically review the efficacy of Saccharomyces boulardii powder in the treatment of antibiotic associated diarrhea（AAD）in children，and provide evidence-based reference for clinical medication. METHODS：Retrieved from Cochrane Library，PubMed，EMBase，Cochrane Controlled Trails Database，CBM，CJFD，VIP and Wanfang database，randomized controlled trials（RCT）about Saccharomyces boulardii powder（test group）versus conventional treatment（control group）in the treatment of AAD in children were collected. Meta-analysis was performed by using Rev Man 5.0 software after quality assessment and data extract. RESULTS：A total of 6 RCTs were included，involving 746 patients. Results of Meta-analysis showed effective rate [RR＝1.21，95％CI（1.08，1.35），P＜0.001]，cure rate [RR＝1.81，95％CI（1.48，2.20），P＜0.001] and duration of diarrhea [MD＝－1.95，95％CI（－2.56，－1.34），P＜0.001] in test group were significantly better than control group，the difference was statistically significant. CONCLUSIONS：Saccharomyces boulardii powder can effectively treat the AAD in children.