OBJECTIVE： To explore the method and role of clinical pharmacists in pharmaceutical care for nephrotic syndrome complicated with Pneumocystis carinii pneumonia （PCP）. METHODS： Clinical pharmacists participated in the treatment for a patient with nephrotic syndrome complicated with PCP， and implemented pharmaceutical care in terms of the development of anti-infective therapy regimens， glucocorticoid optimization， guardianship for drug use， the medication education for patients. Clinical pharmacists provided suggestion that primary anti-infective plan of azithromycin 0.5 g，ivgtt，qd+Compound sulfalene tablet 2 tablets， po， q12 h； which was not effective，was adjusted plan as Compound sulfalene tablet 3 tablets， po， q6 h+clindamycin 0.6 g， ivgtt， q8 h+caspofungin 50 mg， ivgtt， qd. The dose of Methylprednisolone for injection was adjusted 4 times according to disease progression. RESULTS： Physicians adopted the suggestions of clinical pharmacists. After 30 days of treatment，  lung abnormal lesion was absorbed basically and infection control was achieved. CONCLUSIONS： Clinical pharmacists participate in anti-infective treatment and pharmaceutical care， and assist physicians to develop therapy plan to promote rational drug use in the clinic and improve the effectiveness and safety of clinical treatment.