OBJECTIVE： To promote drug storage work by adopting speech picking technology. METHODS： To establish general speech library by using text-to- speech （TTS） technology， voice IP transmission technology and automatic speech recognition （ASR） technology， made server intelligent robot and picking staff carried equipment with them for voice interaction when picking drugs （out of storage， inventory） in drug storage. Under traditional paper list mode and speech picking technology mode， the time of out of storage and inventory， the number of delivery error were compared. RESULTS & CONCLUSIONS： The speech picking technology can improve the efficiency of drug picking and reduce error rate with the advantage of hands and eyes-free， multiple validation. Compared with traditional mode， out of storage efficiency is increased by 51.5％ and inventory efficiency by 55.9％， and delivery error rate is decreased by 63.9％； the technology realize the paperless drug delivery. The technology can improve the informationization of pharmaceutical affairs management， should be further promoted in drug storage work.